Curcumin Inhibits the Spread of
Endometrial Cancer

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September 13, 2018

By Susan Callahan, Associate Editor and Featured Columnist

[
Health and fitness articles are reviewed by our team of
Doctors and Registered Nurses, Certified fitness trainers and
other members of our Editorial Board
.]






Once you have received "the news" that you have
endometrial cancer, it's important to kick into another gear
about your health.  Yes, do all the doctor asks you to do and
follow the recommended therapies. But you should also
discuss with your doctor natural herbs and other remedies
that scientists have found can support your recovery.  
Curcumin is one such remedy.



Curcumin is an ancient spice that has been used for
thousands of years in India and the Orient. Curcumin gives
curry its yellow color.  In Asian societies, curcumin is used as
a traditional medicine for many purposes. We have written
before about
curcumin's use in breast cancer therapies.

There are two types of endometrial cancer. Type I
endometrial cancer is considered a low risk cancer that is
treatable.  Type II endometrial cancer involves invasion of
the middle layer of the uterine wall called the "myometrium"
and lymph nodes and has a high mortality.

Why Is Curcumin Effective Against a Number of Cancers?

Cancer grows using many different chemical pathways, only
some of which can be inhibited by current drug therapies.

Curcumin acts against 26 potential pathways that cancer
uses to originate, grow in place and then metasticize outside
the original location.

In 2015, scientists from The Second Affiliated Hospital,
Medical School of Xi'an Jiaotong University set out to find
out of curcumin could also work to inhibit the spread of
endometrial cancer cells. It does.


First, a bit of background. The study found that curcumin
suppresses a communication/signalling pathway needed for
cancer to spread. The MAPK/ERK pathway (also known as
the Ras-Raf-MEK-ERK pathway) is a chain of proteins a cell
uses to send a signal from a receptor on the surface of the
cell to the DNA in the nucleus of the cell.

To test how curcumin affects these signals, the scientists
added curcumin to lab dishes containing endometrial cancer
cells. When curcumin was added, the cells stop spreading.

This is the study's conclusion:

"In conclusion, curcumin inhibits tumor cell migration and
invasion by reducing the expression and activity of MMP-2/9
via the suppression of the ERK signaling pathway,
suggesting that curcumin is a potential therapeutic agent for
EC[endometrial cancer]".



Some Health Authorities Are Skeptical of Curcumin's
Usefulness Against Cancer































Cancer Research UK is one of several health authorities that
caution against believing that curcumin can "cure" cancer.

This organization points out that there is no definitive
research showing that curcumin stops cancer and that more
research is needed. It states that the several studies
showing that curcumin inhibits the spread of various cancers
"look promising but we need to do more clinical trials in
humans before we will know if curcumin has any potential to
treat cancer in people."

We agree that more human studies are needed.

But we also find that adding curcumin as a spice to your
soups, chilies and sauces cannot hurt and may in fact help.

There is one proven danger of curcumin. Curcumin is a
natural blood thinner. If you are already taking blood
thinning medications, you cannot take curcumin without first
consulting with your doctor. Make sure your doctor knows
how much curcumin you plan to take.











































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